Endocrinology and Cell Biology
A-2, Greater Azad Resiplex, Dhorra, Aligarh
Dr. M. Arshad completed his B.Sc. (Hons.) and M.Sc. (Zoology) degree from Aligarh Muslim University (AMU), Aligarh, India, and Ph.D. degree from Central Drug Research Institute (CSIR-CDRI), Lucknow, India. He subsequently worked as a postdoctoral research fellow at the Department of Cellular and Molecular Biology, Center of Osteo-Articular and Dental Tissue Engineering, University of Nantes, France. On his return to India, he was appointed as an Assistant Professor at the Department of Zoology, University of Lucknow. He recently joined the Department of Zoology at AMU as an Associate Professor.
Dr. Arshad’s core research interests lie in the areas of endocrinology and cell biology. His research work is centered on hormonal regulation of bone metabolism, cellular and molecular mechanism of bone remodeling, cross talk of bone and cartilage cells, characterization of promising therapeutics for postmenopausal osteoporosis, diabetic osteopathy, osteoarthritis and endocrine cancer, using cell culture and animal models. He has established a base line data of bone turnover rate in rat model in relation to estrous cycle, pregnancy and lactation. He studied relation of vitamin D receptor gene polymorphism with bone mineral density in north Indian postmenopausal women. Currently he is working on the characterization of fish derived collagen and fatty acids targeting its effect on osteoblast/osteoclast/chondrocyte proliferation and apoptosis.
He has published more
than eighty research papers and review articles in high impact, reputed journals
like Cell Proliferation, Cell Biology International, Gene, Journal of Steroid
Biochemistry and Molecular Biology, Journal of Ethnopharmacology, Nutrition and
Cancer, PLOS ONE, Acta Pharmaceutica Sinica B etc. He has also edited two books.
He has been a Principal Investigator/Co-investigator of several major research projects funded by the DST-SERB, ICMR, UGC and UP-CST and has supervised/mentored a number of doctoral students and post doctoral research fellows.
- Key Publications
Shivnath N, Siddiqui S, Rawat V, Khan MS, Arshad M. Solanum xanthocarpum fruit extract promotes chondrocyte proliferation in vitro and protects cartilage damage in collagenase induced osteoarthritic rats. Journal of Ethnopharmacology (2021) 274, 114028. IF:4.36.
Shivnath N, Rawat V, Siddiqui S, Verma S, Gupta P, Rais J, Khan MS, Arshad M. Antiosteoarthritic effect of Punica granatum L. peel extract on collagenase induced osteoarthritis rat by modulation of COL?2, MMP?3, and COX?2 expression. Environmental Toxicology (2021) 36 (1), 5-15. IF:3.179
Fatima N, Upadhyay T, Ahmad F, Arshad M, Kamal MA, Sharma D, Sharma R. Particulate ?-glucan activates early and delayed phagosomal maturation and autophagy within macrophage in a NOX-2 dependent manner. Life Sciences (2021) 266: 118851. doi.org/10.1016/j.lfs.2020.118851. IF: 5.03
Siddiqui S, Mahdi AA, Arshad M. Genistein contributes to cell cycle progression and regulates oxidative stress in primary culture of osteoblasts along with osteoclasts attenuation. BMC Complementary Medicine and Therapies (2020) 20(1):1-11. IF: 3.47.
PR Jagdale PR, I Dev I, A Ayanur A, D Singh D, Arshad M. Ansari KM, Safety evaluation of Ochratoxin A and Citrinin after 28 days repeated dose oral exposure to Wistar rats. Regulatory Toxicology and Pharmacology (2020) 115: 104700. doi.org/10.1016/j.yrtph.2020.104700. IF: 3.27.
Hussain A, C Gautam, Jafri A, Mishra VK, Madheshiya A, Gautam A, Singh MK, Gautam RK, Gautam M, Arshad M, Vajtai R, Ajayan PM. Formation of multifunctional ZrO2–MgO-hBN nanocomposite for enhanced bone regeneration and E. coli bacteria filtration applications. Ceramics International (2020) 46(14): 23006-23020. IF: 4.52
Jafri A, Siddiqui S, Rais J, Ahmad MS, Kumar S, Jafar T, Afzal M, Arshad M. Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation. EXCLI Journal. (2019)18:154-164.IF: 4.06
Azad I, Jafri A, Khan T, Akhter Y, Arshad M, Hasan F, Ahmad N, Khan AR, Naseebullah M. Evaluation of pyrrole-2,3-dicarbaxylatederivatives: Synthesis, DFTanalysis, molecular docking, virtual screening and in vitro anti-hepatic cancer study. Journal of Molecular Structure (2019) 1176: 314-334.IF: 3.19
Ahmad I, Jafar T, Mahdi F, Ameta K, Arshad M, Das SK, Waliullah S, Rizvi I, Mahdi AA. Association of vitamin D receptor gene polymorphism (TaqI and Apa1) with bone mineral density in north Indian postmenopausal women. Gene (2018) 659: 123-127. IF: 3.68
Siddiqui S, Ahamad MS, Jafri A, Afzal M, Arshad M. Piperine triggers apoptosis of human oral squamous carcinoma through cell cycle arrest and mitochondrial oxidative stress. Nutrition and Cancer (2017) 69(5):791-799.IF: 2.36
Kirwen EM, Batra T, Karthikeyan C, Deora GS, Rathore V, Mulakayala C, Mulakayala N,Nusbaum AC, Chen J, Amawi H, McIntosh K, Sahabjada,Shivnath N, Chowarsia D, Sharma N, Arshad M, Trivedi P,Tiwari AK, 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents. Acta Pharmaceutica Sinica B (2017) 7(1): 73–79.IF: 11.41
Kaleem S, Siddiqui S, Siddiqui HH, Hussain A, Arshad M, Akhtar J, Rizvi A. Eupalitin induces apoptosis in prostate carcinoma cells through ROS generation and increase of caspase?3 activity. Cell Biology International (2016) 140(2):196-203.IF: 3.612
Jigyasu AK, Siddiqui S, Lohani M, Khan IA, Arshad M. Chemically synthesized CdSe quantum dots inhibit growth of human lung carcinoma cells via ROS generation. EXCLI Journal (2016) 15:54-63.IF: 4.06
Shanmugaprakash M, Jayashree C, Vinothkumar V, Senthilkumar SNS, Siddiqui S, Rawat V, Arshad M. Biochemical characterization and antitumor activity of three phase partitioned L-asparaginase from Capsicun annuum L. Separation and Purification Technology (2015) 142:258-267. IF: 7.312
Siddiqui S, Ahmad E, Gupta M, Rawat V, Shivnath N, Banerjee M, Khan MS, Arshad M.Cissusquadrangularis Linn exerts dose?dependent biphasic effects: osteogenic and anti?proliferative, through modulating ROS, cell cycle and Runx2 gene expression in primary rat osteoblasts. Cell Proliferation (2015) 48(4):443-54.IF: 6.83
Siddiqui S, Arshad M. Osteogenic potential of Punica granatum through matrix mineralization, cell cycle progression and runx2 gene expression in primary rat osteoblasts. DARU Journal of Pharmaceutical Sciences.(2014) 22(1):72. IF: 3.11
Ahamad MS, Siddiqui S, Jafri A, Ahmad S, Afzal M, Arshad M. Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest. PloS One (2014) 9(10):e110003.IF: 2.74
Faucheux C, Verron E, Soueidan A, Josse S, Arshad M, Janvier P, Pilet P, Bouler JM, Bujoli B, Guicheux J. Controlled release of bisphosphonate from a calcium phosphate biomaterial inhibits osteoclasticresorption in vitro. Journal of Biomedical Materials Research Part A (2009) 89(1):46-56.IF: 4.39
Srivastava M, Mandal SK, Sengupta S, Arshad M, Singh MM. Quantification of bone mineral density to define osteoporosis in rat. Journal of Endocrine Investigation (2008) 31(5):393 IF: 4.25
Arshad M, Sengupta S, Sharma S, Ghosh R, Sawlani V, Singh MM. In vitro anti-resorptive activity and prevention of ovariectomy-induced osteoporosis in female Sprague–Dawley rats by ormeloxifene, a selective estrogen receptor modulator. Journal of Steroid Biochemistry and Molecular Biology (2004) 91(1):67-78.IF: 4.29