Prof. Aijaz Ahmed Khan





    Neuroanatomy, Microanatomy and Interdisciplinary collaborations in the field of nanotechnology, hepato-and nephrotoxicity


    141, Street -4, GR. Azad Encl, Dhorra, Aligarh-202002




Dr. Aijaz Ahmed Khan did his MBBS and MS (Anatomy) from KGMC, Lucknow and PhD from AIIMS, New Delhi. He joined AMU as Lecturer in 1990 and was promoted to Reader and Professor in 1998 and 2006 respectively. He has overseas teaching experience of 05 years in USM, Malaysia and CHS, KSA. He takes keen interest in teaching neuroanatomy and microscopic anatomy and has co-authored four books on gross and microscopic anatomy and five book chapters on different interesting medical topics. He has supervised over dozen of MS/MD/PhD theses and has published more than hundred research papers. His research works in the field of neuroscience have been published in reputed international journals like - Cells Tissues and Organs; Developmental neuroscience and International journal of neuroscience. His interdisciplinary collaborative research works have also been published many reputed international journals like Molecular Medicine; Nanomedicine; PLoS ONE; International J of Nanomedicine; Int. J Applied Biology & Pharmaceutical Technology; Experimental & Toxicologic Pathology; Applied Microbiology & Biotechnology, Biochimie etc. His current research interest includes: effects of experimental hyperglycemia on the discrete parts of nervous system; experimental study on the application of polymer nanocomposite materials in healing of bone defects and microscopy anatomy of ear ossicles and their joints.
  1. Key-Publications


    Elsy B & Khan AA (2020): Normal progressive developmental stages of the

    pilosebaceous unit in the albino rat’s skin - A light microscopic study. Our Dermatology Online.  3,2020, P-231-237.

    Jolly R, Khan AA, Ahmed SS, Alam S, Kazmi S, Owais M, Farooqi MA & Shakir MA (2020): Bioactive Phoenix dactilofera seeds incorporated chitosan/ hydroxyapatite nanoconjugate for prospective bone tissue engineering applications: A biosynergistic approach.  Materials Science & Engineering C 109 (2020) 110554.

    Ansari FA, Ali SN, Khan AA and Mahmood R (2019): Ameliorative effect of carnosine and N-acetylcystine against sodium nitrite induced nephrotoxicity in rats. J Cell Bioch.120:7032-7044.

    Ali SN, H Arif, Khan AA and Mahmood R (2018): Acute renal toxicity of sodium chlorate: Redodx imbalance, enhanced DNA damage, metabolic alterations and inhibition of brush border enzymes in rats. Environ.Toxicol. 33:1182-1194. 

    Elsy B, Khan AA and Maheshwari V (2018): Co-Administered Vitamin E Isoforms d-?-tocopherol and d-?-tocotrienol Rich Fraction Promote Regeneration of Skeletal Muscle in Diabetics. Int. J. Nutri. & Food Sci. 7: 47-55.

    Ansari FA, Khan AA, Mahmood R (2018): Protective effect of carnosine and N-acetylcysteine against sodium nitrite-induced oxidative stress and DNA damage in rat intestine. Environ. Sci. & Pollution Res. 1-13.

    Shahid F, Farooqui Z, Khan AA, Khan F (2018): Oral Nigella sativa oil and thymoquinone administration ameliorates the effect of long-term cisplatin treatment on the enzymes of carbohydrate metabolism, brush border.membrane, and antioxidant defense in rat intestine. Naunyn-Schmiedeberg's archives Pharmacol. 391: 145–157.

    Shakir M, Jolly R, Khan AA, Ahmed SS, Alam S, Rauf MA, Owais M, Farooqi MA (2018): Resol based chitosan/nao-hydroxyapatite nanoensemble for effective bone tissue engineering. Carbohydrate polymers 179: 317-327.

    Ansari FA, Ali SN, Khan AA and Mahmood R (2018): Acute oral dose of sodium nitrite causes redox imbalance and DNA damage in rat kidney

    J.  Cell. Biochem. 119: 3744-3754.

    Elsy B, Khan AA and Maheshwari V (2017): Effects of d- -tocopherol on skeletal muscle regeneration in crushed injury of diabetic rats. Eur. J. Anat. 21:293-304

    Elsy B, Khan AA and Maheshwari V (2017): Regenerative potential of d-?-tocotrienol-rich fraction on crushed skeletal muscle of diabetic rats. J. Interdispl. histopathol. 5: 36-42.

    Ansari FA, Ali SN, Arif H, Khan AA and Mahmood R (2017): Acute oral dose of sodium nitrite induces redox imbalance, DNA damage, metabolic and histological

    changes in rat intestine. PLOS ONE |

    Elsy B, Khan AA and Maheshwari V (2017): Therapeutic potential of d-?-tocotrienol rich fraction on excisonal skin wounds in diabetic rats –Our dermatol. online. 8: 376-384.

    Elsy B, Khan AA and Maheshwari V (2017): Effect of Co-Administration of Vitamin E Isoforms d- -Tocopherol and d-?-Tocotrienol Rich Fraction on the Healing of Skin Wounds in Diabetic Rats - In. j Biomed. Engg. Clinic. Sci. 3: 52-62.

    Ali S, Ansari FA, Khan AA and Mahmood R (2017): Sodium chlorate, a major water disinfection byproduct, alters brush border membrane enzymes, carbohydrate metabolism and impairs antioxidant system of Wistar rat intestine. Environ.Toxicol.32:1607-1616 doi: 10.1002/tox.22388.

    Farooqui Z, Ahmed F, Rizwan S, Shahid F, Khan AA and Khan F (2017): Protective effect of Nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney. J Biomed. Pharmacotherapy. 85: 7-15.

    Elsy B, Maheshwari V and Khan AA (2016): Effects of d a-Tocopherol on Progression of Reepithelialization, Matrix Remodeling and Appearance of Epidermal Appendages in Secondary Skin Wounds of Diabetic Rats. J Dermatol. & Clinic. Res. 4: 1081-1087

    Farooqui Z, Afsar M, Rizwan S, Khan AA and Khan F (2016): Oral administrationof Nigella sativa oil ameliorates the effect of cisplatin on membrane enzymes,carbohydrate metabolism and oxidative damage in rat liver. Toxicol. Reports. 3:328-325.

    Sherwani MA, Tufail S, Khan AA and b and Owais M (2016): Dendrosome mediated topical gene silencing by PLK-1 specific siRNA: implication in treatment of skin cancer in mouse model. RSC Adv., 6: 6843-6857.

    Sherwani MA, Tufail S, Khan AA and b and Owais M (2015): Gold Nanoparticle-Photosensitizer Conjugate Based Photodynamic Inactivation of Biofilm Producing Cells: Potential for Treatment of C. albicans Infection in BALB/c Mice PLoS ONE 10(7): e0131684. doi:10.1371/journal.pone.0131684.

    Ansari MA, Khan HM, Kahan AA and Alzohairy MA (2015): Biochemical and histopathological ultrastructural changes caused by ZnO nanoparticles in mice.

    Toxicol. & Environ. Chem. 1-20.

    Sherwani MA, Tufail S, Khan AA and b and Owais M (2015): Dendrimer-PLGA based multifunctional immunonanocomposite mediated synchronous and tumor selective delivery of siRNA and cisplatin: potential in treatment of hepatocellular carcinoma† Cite this: RSC Adv., 2015, 5, 39512, The Royal Society of Chemistry (RSC Adv). 2015, 5, 39512–39531.

    Ahmad MK, Khan AA, Ali SN & Mahmood R (2015): Chemoprotective Effect of Taurine on Potassium Bromate-Induced DNA Damage, DNA-Protein Cross-Linking and Oxidative Stress in Rat Intestine. PLoS One 6;10(3):e0119137.

    Zia Q, Khan AA, Swaleha Z and Owais M (2015): Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans. Int. J Nanomed. 10: 1769-1790.

    Ansari MA, Khan HM, Khan AA, Alzohairy MA,Waseem M, Ahmad MK and Mahdi AA, (2015): Biochemical. Histopathological, andTransmission Electron Microscopic Ultrastructural Changes in Mice After Exposure to Silver Nanoparticles. Environ. Toxicol. DOI 10.1002/to (12 pages).

    Ansari MA, Khan HM, Khan AA, Cameotra SS, MA Alzohairy MA (2015): Antibiofilm effi cacy of silver nanoparticles against MRSA and MRSE isolated from11wounds in a tertiary care hospital. In. J. Med. Microbiol, 33: 101-109.

    Ansari MA, Khan HM, Khan AA, Musarrat J, Cameotra SS (2014). Gum arabic capped-silver nanoparticles inhibit biofilm formation by multidrug resistance strains of Pseudomonas aeruginosa. J. Basic Microbiol. 54: 1-12.

    Farazuddin M, Dua B, Zia Q, Khan AA, Joshi B & Owais M (2014): Chemotherapeutic potential of Curcumin-bearing microcells against hepatocellular carcinoma in model animals. Int. J Nanomed 9: 1139-1152;

    Ansari MA, Khan HM, Khan AA, Cameotra SS, Musarrat J (2014). Interaction of Al2O3 nanoparticles with Escherichia coli and their cell envelope biomolecules. J Appl. Microbiol. 116: 772-783.

    Ahmad MK, Khan AA & Mahmood R (2013): Taurine ameliorates potassium bromated-induced kidney damage in rats. Amino Acids. 45: 1109-1121.

    Hassan I, Chibber S, Khan AA and Naseem I (2013): Cisplatin-Induced Neurotoxicity In Vivo Can Be Alleviated by Riboflavin Under Photoillumination Cancer Biotherapy & Radiopharmaceuticals. 28: 160-168.

    Ansari MA, Khan HM, Khan AA, Cameotra SS and Pal R (2013}: Antibiofilm efficacy of silver nanoparticles against biofilm of extended spectrum b-lactamase isolates of Escherichia coli and Klebsiella pneumonia. Appl. Nanosci. Sept. DOI 10.1007/s13204-013-0266-1. 

    Ansari MA, Khan HM, Khan AA, Pal R and Cameotra SS (2013}: Antibacterial potential of  Al2O3  nanoparticles  against  multidrug  resistance  strains  of Staphylococcus aureus isolated from skin exudates. J Nanopart. Res.15: 1-12.

    Tripathi T, Khan AA, Shahid M, Khan HM, Siddiqui M, Khan RA, Mahdi AA,

    and Malik A (2013): Biochemical Alteration on Hepatic Functions by Histamine H3-Receptor Agonist and Antagonist in the Immunized Rabbits. Bratislava Med. J. 114: 675-68.

    Khan Azmat Ali, Jabeen M, Khan AA and Owais M (2013): Anticancer efficacy of a novel propofol-linoleic acid-loaded escherichiosomal formulation against murine hepatocellular carcinoma. Nanomed, 8:1281-1294.

    Tripathi T, Khan AA, Shahid M, Khan HM, Siddiqui M, Khan RA, Mahdi AA, Abida Malik, (2013): Biochemical & Histopathological Evaluation of Histamine Receptors (H1R, H3R, H3R and H4R) Agonists in Rabbit. Exp. Toxicol Pathol. 65: 271-275.

    Tripathi T, , Shahid M, Khan MH, , Khan RA, Mahdi AA, Siddiqui M, Malik  A & Khan AA (2012): Dose-dependent effect of histamine on liver function markers in immunized Rabbits. Exp. Toxicol Pathol. 64: 875-881.

    Ahmad MK, Khan AA and Mahmood R (2012): Alteration in brush border enzymes, carbohydrate metabolism and oxidative damage to rat intestine by potassium bromated. Biochimie 94: 2776 – 2782.

    Hassan I, Chibber S, Khan AA and Naseem I (2012): Riboflavin ameliorates cisplatin induced toxicities under photoillumination. PloS ONE. PONE-D-11-21563R2: vol7, Issue-5, e36273.

    Farazuddin M, Sharma B, Khan AA, Joshi B and Owais M (2012): Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles. Int. J Nanomed.7: 35-47.

    Tripathi T, Khan AA, Shahid M, Khan HM, Siddiqui M, Khan RA and Mahdi AA (2012): Immunological, biochemical and histopathological evaluation of histamine receptors (H1R,H2R, H3R and H4R)-antagonist in rabbit experimental model: a short term study. Exp. & Toxicol. Pathol. 64:259-66.

    Ansari MA, Khan MH, Khan AA, Sultan A and Azam A (2012): Characterization of clinical strains of MSSA, MRSA and MRSE isolated from skin and soft tissue infections and the antibacterialactivity of ZnO nanoparticles. World J Microbiol. Biotechnol. 28:1605–1613.

    Tripath T, Shahid M, Raza A, Khan HM, Siddiqui M, Khan RA, Mahdi AA, Siddiqui M, Malik A and Khan AA (2012): Dose-dependent effect of histamine on liver function markers in immunized rabbits. Exp Toxicol Pathol. 64:875-81.

    Ansari MA, Khan MH, Khan AA, Sultan A, Azam A, Shahid M & Shujatullah F (2011): Antibacterial activity of silver nanoparticles dispersion against MSSA and MRSA isolated from wounds in tertiary hospital of North India. Int. J Appl. Biol. & Pharmaceut. Technol. 2: 34-42.

    Ansari MA, Zubair S, Mahmood A, Gupta P, Khan AA, et al. (2011) RD Antigen Based Nanovaccine Imparts Long Term Protection by Inducing Memory Response against Experimental Murine Tuberculosis. PLoS ONE 6(8): e22889. doi:10.1371/journal.pone.0022889 (MA = Mairaj Ahmad).

    Tripathi T, Shahid M, Khan HM, Khan AA, Siddiqui M and Khan RA (2010): In vivo study of Histamin H3-receptor in immunomodulation World Appl. Sci. J. 9 : 1213-1222.

    Tripathi T, Khan AA, Khan, Shahid M, Khan HM, Sidduqui M, Khan RA and Mehdi AA (2010): Hepatotoxicity due to HTMT, Amthamine, R-(-)- ?-Methyle and Clobenpropit (H1R-H4R-Agonists, Respectively) in Rabbit Experimental Model. American Medical J. 6: 1-7.

    Alam M, Dwivedi V, Khan AA and Mohammad O (2009): Efficacy of niosomal formulation of diallyl sulfide against experimental candidiasis in Swiss albino mice. Nanomed. 4:713-24.

    Khan Arif, Khan AA, Dwivedi V, Ahmad MG, Hakeem S and Owais M (2007): Tuftsin augments antitumor efficacy of liposomized etopside against fibrosarcoma in Swiss albino mice. Mol Med 13: 266-276.

    Khan AA (2004): Wallerian degeneration in the optic nerve of rabbit. Cells Tissues Organs. 177: 104-109.

    Khan AA, Wadhwa S, and Bijlani V (1994): Development of human lateral geni-culate nucleus: an electron microscopic study. Int. J. Dev. Neurosci. 12: 661- 672.

    Khan AA, Wadhwa S, and Bijlani V (1993): Prenatal human lateral geniculate nucleus - a quantitative light microscopic study. Dev. Neurosci. 15: 403-409.

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