DEPARTMENT.FACULTY

photo
Prof. Mohammad Tabish
  • DEPARTMENT_STAFF.QUALIFICATION

    M.Sc, Ph.D

  • DEPARTMENT_STAFF.DESIGNATION

    Professor

  • DEPARTMENT_STAFF.THRUST_AREA

    Transcriptomics, Bioinformatics, drug interaction with DNA/protein

  • DEPARTMENT_STAFF.ADDRESS

  • DEPARTMENT_STAFF.MOBILE

    +91-9634780818

  • DEPARTMENT_STAFF.EMAIL

    tabish.biochem@gmail.com

DEPARTMENT_STAFF.COMPLETE_CV
Research interest: The regulation of human gene expression is known to be an extraordinarily complex process, including transcription, mRNA processing, mRNA transport, mRNA stability, mRNA translation, protein modification and protein stability. Alternative splicing of a single pre-mRNA can give rise to different mRNA transcripts consequently, generating protein diversity from a single gene. In humans, it is estimated that more than 70% of human protein coding genes undergo alternative splicing. Alternative splicing is found extensively in all higher eukaryotes. We are working on different class of genes (protein kinase A, neurotransmitter receptors, cancer associated genes etc.) which generate multiple transcripts after transcription and alternative splicing of their respective pre-mRNA. We also study the transcript isoforms and encoded proteins that are differentially expressed in different cell/tissue types. Teaching interest: Biotechnology, molecular biology and bioinformatics.
  1. Publications in International Journals

    2023

    1.        Hussain I, Fatima S, Ahmed S, Tabish M. (2023). Biophysical and molecular modelling analysis of the binding of b-resorcylic acid with bovine serum albumin. Food Hydrocolloids 135: 108175. (In Press).

    2.        Fatima S, Hussain I, Ahmed S, Tabish M. (2023). In vitro and in silico binding studies of phytochemical isochroman with calf thymus DNA using multi-spectroscopic and computational modelling techniques. J. Biomolecular Structure and Dynamics. (In Press).


    2022

    3.        Ahmed S, Rehman SU, Tabish M. (2022). Cancer nanomedicine: a step towards improving the drug delivery and enhanced efficacy of chemotherapeutic drugs. OpenNano, 100051.

    4.        Parveen M, Azeem M, Aslam A, Azam M, Siddiqui S, Tabish M, Malla AM, Min K, Rodrigues VH, Al-Resayes SI, Alam M. (2022). Isolation, Identification, Spectral Studies and X-ray Crystal Structures of Two Compounds from Bixa orellana, DFT Calculations and DNA Binding Studies. Crystals 12 (3), 380.

    5.        Parveen M, Aslam A, Siddiqui S, Tabish M, Alam M. (2022). Structure elucidation, DNA binding and molecular docking studies of natural compounds isolated from Crateva religiosa leaves. Journal of Molecular Structure 1251, 131976.

    6.        Afrin S, Rahman Y, Sarwar T, Ansari MO, Ahmed S, Rizvi MA, Shadab GGHA, Tabish M. (2022). Cytotoxic and genotoxic evaluation of dipyridamole and its alternative therapeutic potential in cancer therapy: an in vitro and in vivo approach. Journal of Molecular Structure. 1249, 131626.

    7.        Ameen F, Siddiqui S, Jahan I, Nayeem SM, Rehman SU, Tabish M. (2022). Studying the interaction of scopolamine with calf-thymus DNA: An in-vitro and in-silico approach and genotoxicity. Spectrochim. Acta A Mol Biomol Spectrosc. 15:265:120391. doi: 10.1016/j.saa.2021.120391. PMID: 34571375.

    8.        Ameen F, Siddiqui S, Kausar T, Nayeem SM, Sarwar T, Rizvi MMA, Rehman SU, Tabish M. (2022). Interaction of memantine with calf thymus DNA: an in-vitro and in-silico approach and cytotoxic effect on the cancerous cell lines. J Biomol Struct Dyn. 40(3):1216-1229. doi: 10.1080/07391102.2020.1823886. PMID: 32954978.

    9.        Hussain I, Fatima S, Ahmed S, Tabish M. (2021). Deciphering the biomolecular interaction of b-resorcylic acid with human lysozyme: A biophysical and bioinformatics outlook. J. Molecular Liquids. 346: 117885.


    2021

    10.    Rahman Y, Afrin S, Perwez A, Ansari MO, Sarwar T, Ahmed S, Rizvi MA, Shadab GGHA, Tabish M. (2021). Nizatidine interacts with ct-DNA causing genotoxicity and cytotoxicity: an assessment by in vitro, in vivo, and in silico studies. J Biomol Struct Dyn. 3:1-12. doi: 10.1080/07391102.2021.2008496. Online ahead of print. PMID: 34856883.

    11.    Hussain I, Fatima S, Siddiqui S, Ahmed S, Tabish M. (2021). Exploring the binding mechanism of ?-resorcylic acid with calf thymus DNA: Insights from multi-spectroscopic, thermodynamic and bioinformatics approaches. Spectrochim Acta A Mol Biomol Spectrosc. 260:119952. doi: 10.1016/j.saa.2021.119952.

    12.    Siddiqui S, Ameen F, Rehman SU, Sarwar T, Tabish M. (2021). Studying the interaction of drug/ligand with serum albumin Journal of Molecular Liquids, 116200.

    13.    Fatima S, Ansari S, Bano S, Ahamad S, Ishqi HM, Tabish M, Gupta D, Rehman SU, Jairajpuri MA. (2021). Detection of truncated isoforms of human neuroserpin lacking the reactive center loop: Implications in non-inhibitory role. IUBMB Life. 73 (7): 941-952. doi: 10.1002/iub.2475.

    14.    Siddiqui S, Ameen F, Kausar T, Nayeem SM, Ur Rehman S, Tabish M. (2021). Biophysical insight into the binding mechanism of doxofylline to bovine serum albumin: An in vitro and in silico approach. Spectrochim Acta A Mol Biomol Spectrosc. 249:119296. doi: 10.1016/j.saa.2020.119296.

    15.    Siddiqui S, Mujeeb A, Ameen F, Ishqi HM, Rehman SU, Tabish M. (2021). Investigating the mechanism of binding of nalidixic acid with deoxyribonucleic acid and serum albumin: a biophysical and molecular docking approaches. J Biomol Struct Dyn. 39: 570-585. doi: 10.1080/07391102.2020.1711808.


    2020

    16.    Ameen F, Siddiqui S, Jahan I, Nayeem SM, Rehman SU and Tabish M. (2020). A detailed insight into the interaction of memantine with bovine serum albumin: A spectroscopic and computational approach. J. Molecular Liquids 303: 112671 Online ahead of print.

    17.    Bano S, Fatima S, Ahamad S, Ansari S, Gupta D, Tabish M, Rehman SU, Jairajpuri MA. (2020). Identification and characterization of a novel isoform of heparin cofactor II in human liver. IUBMB Life. 72: 2180-2193. doi: 10.1002/iub.2361.

    18.    Rehman SU, Tabish M. (2020). Alternative splicing of ACE2 possibly generates variants that may limit the entry of SARS-CoV-2: a potential therapeutic approach using SSOs. Clin Sci (Lond). 134(10):1143-1150. doi: 10.1042/CS20200419.

    19.    Rahman Y, Afrin S, Alhaji Isa M, Ahmed S, Tabish M. (2020). Elucidating the molecular interaction of serum albumin with nizatidine and the role of ?-cyclodextrin: multi-spectroscopic and computational approach. J. Biomol Struct and Dyn. 38(5): 1375-1387. doi: 10.1080/07391102.2019.1604265.

    20.    Afrin S, Rahman Y, Isa MA, Ahmed S, Tabish M. (2020).  Biophysical insights into the binding characteristics of bovine serum albumin with dipyridamole and the influence of molecular interaction with ? cyclodextrin. J. Biomol Struct and Dyn. 38(10): 3046-3058. doi: 10.1080/07391102.2019.1651220.


    2019

    21. Siddiqui S, Ameen F, Jahan I, Nayeem SM, Tabish M. (2019). A comprehensive spectroscopic and computational investigation on the binding of the anti-asthmatic drug triamcinolone with serum albumin. New J. Chem., 43(10): 4137-4151.

    22.    Ansari MO, Parveen N, Ahmad MF, Wani AL, Afrin S, Rahman Y, Jameel S, Khan YA, Siddique HR, Tabish M, Shadab GG. (2019). Evaluation of DNA interaction, genotoxicity and oxidative stress induced by iron oxide nanoparticles both in vitro and in vivo: attenuation by thymoquinone. Sci. Rep., 9(1): 6912. 6912. doi: 10.1038/s41598-019-43188-5.

    23.    Rehman SU, Ashraf S, Ahamad S, Sarwar T, Husain MA, Ahmad P, Tabish M, Jairajpuri MA. (2019). Identification of a novel alternatively spliced isoform of antithrombin containing an additional RCL-like loop. Biochem. Biophys. Res. Commun., 517(3): 421-426. doi: 10.1016/j.bbrc.2019.07.113.

    24.    Afrin S, Rahman Y, Tabish M. (2019). Elucidating the interaction of ticlopidine with serum albumin and its role in bilirubin displacement in vitro. J Biomol Struct Dyn., 37(4):863-876. doi: 10.1080/07391102.2018.1449667.

    2018

    25.    Ishqi HM, Husain MA, Rehman SU, Sarwar T, Tabish M. (2018). Identification and expression of alternatively spliced novel isoforms of cancer associated MYD88 lacking death domain in mouse. Mol Biol Rep., 45(5): 699-711.

    26.    Rahman Y, Afrin S, Tabish M. (2018). Interaction of pirenzepine with bovine serum albumin and effect of ?-cyclodextrin on binding: A biophysical and molecular docking approach. Arch Biochem Biophys., 652: 27-37.

    27.    Ishqi HM, Sarwar T, Husain MA, Rehman SU, Tabish M. (2018). Differentially expressed novel alternatively spliced transcript variant of tumor suppressor Stk11 gene in mouse. Gene, 668: 146-154.


    2017

    28.    Husain MA, Ishqi HM, Sarwar T, Rehman SU, Afrin S, Rahman Y and Tabish M. (2017). Elucidating the interaction of sulindac with calf thymus DNA: biophysical and in silico molecular modelling approach. New J. Chem., 41: 14924-14935.

    29.    Afrin S, Rahman Y, Sarwar T, Husain MA, Ali A, Shamsuzzaman and Tabish M. (2017). Molecular spectroscopic and thermodynamic studies on the interaction of anti-platelet drug ticlopidine with calf thymus DNA. Spectrochim Acta A Mol Biomol Spectrosc., 186: 66-75.

    30.    Rahman Y, Afrin S, Husain MA, Sarwar T, Ali A, Shamsuzzaman and
    Tabish M. (2017). Unravelling the interaction of pirenzepine, a gastrointestinal disorder drug, with calf thymus DNA: An in vitro and molecular modelling study. Arch Biochem Biophys., 625-626: 1-12.

    31.    Rehman AA, Sarwar T, Arif H, Ali SS, Ahsan H, Tabish M. and Khan FH (2017).  Spectroscopic and thermodynamic studies on ferulic acid - alpha-2-macroglobulin interaction. J. Mol. Structure, 1144: 254-259.

    32.    Husain MA, Ishqi HM, Sarwar T, Rehman SU and Tabish M. (2017). Interaction of indomethacin with calf thymus DNA: A Multi-spectroscopic, thermodynamic and molecular modelling approach. Med. Chem. Com., 8: 1283-1296.

    33.    Husain MA, Ur Rehman S, Sarwar T, Ishqi HM and Tabish M. (2017). NSAIDs induced regulation of alternatively spliced transcript isoforms: possible role in cancer and Alzheimer disease. Curr Cancer Drug Targets, 17(5): 467-478.

    34.    Husain MA, Ishqi HM, Sarwar T, Rehman SU and Tabish M. (2017). Identification and expression analysis of alternatively spliced new transcript isoform of Bax gene in mouse. Gene, 621: 21-31.

    35.    Sarwar T, Ishqi HM, Rehman SU, Husain MA, Rahman Y and Tabish M. (2017). Caffeic acid binds to the minor groove of calf thymus DNA: A multi-spectroscopic, thermodynamics and molecular modelling study. Int. J. Biol. Macromol., 98: 319-328.

    36.    Rehman SU, Sarwar T, Husain MA, Ishqi HM and Tabish M. (2017). Identification of two novel isoforms of mouse NUR77 lacking N-terminal domains. IUBMB Life, 69 (2): 106-114.


    2016

    37.    Ishqi HM, Rehman SU, Sarwar T, Husain MA and Tabish M. (2016). Identification of differentially expressed three novel transcript variants of mouse ARNT gene. IUBMB Life, 68: 122-135.

    38.    Rehman SU, Ishqi HM, Husain MA, Sarwar T and
    Tabish M. (2016). A novel exon generates ubiquitously expressed alternatively spliced new transcript of mouse Abcc4 gene. Gene, 594: 131-137.

    39.    Parveen M, Ahmad F, Malla AM, Khan MS, Rehman SU, Tabish M, Silva MR and Silva PS (2016). Structure elucidation and DNA binding specificity of natural compounds from Cassia siamea leaves: A biophysical approach. J. Photochem. Photobiol. B., 159: 218-228.

    2015

    40.    Sarwar T, Rehman SU, Husain MA, Ishqi MH, and Tabish M. (2015). Interaction of coumarin with calf thymus DNA: Deciphering the mode of binding by in vitro studies. Int. J. Biol. Macromol., 73: 9-16.

    41.    Rehman SU, Zubair H, Sarwar T, Husain MA, Ishqi MH, Nehar S and Tabish M. (2015). Redox cycling of Cu(II) by 6 Mercaptopurine leads to ROS generation and DNA breakage: possible mechanism of anticancer activity. Tumor Biol., 36: 1237-1244.

    42.    Sarwar T, Husain MA, Rehman SU, Ishqi MH and Tabish M. (2015). Multi-spectroscopic and molecular modelling studies on the interaction of esculetin with calf thymus DNA. Molecular Biosyst., 11(2): 522-531.

    43.    Rehman SU, Sarwar T, Ishqi HM, Husain MA, Hasan Z and Tabish M. (2015). Deciphering the interactions between chlorambucil and calf thymus DNA: A multi-spectroscopic and molecular docking study. Arch. Biochem. Biophys., 566: 7-14. Cover of the issue was from this paper

    44.    Husain MA, Sarwar T, Rehman SU, Ishqi HM and Tabish M. (2015). Ibuprofen causes photocleavage through ROS generation and intercalates with DNA: A combined biophysical and molecular docking approach. Phys. Chem. Chem. Phys., 17: 13837-13850.

    45.    Rehman SU, Husain MA, Sarwar T, Ishqi HM and Tabish M. (2015). Modulation of alternative splicing by anticancer drugs. Wiley Interdiscip. Rev. RNA, 6(4): 369-379.

    46.    Rehman SU, Sarwar T, Husain MA, Ishqi HM and Tabish M. (2015). Studying non-covalent drug-DNA interactions. Arch. Biochem. Biophys., 576: 49-60.

    47.    Sarwar T, Zafaryab M, Husain MA, Ishqi HM, Rehman SU, Rizvi MM and Tabish M. (2015). Redox cycling of endogenous copper by ferulic acid leads to cellular DNA breakage and consequent cell death: A putative cancer chemotherapy mechanism. Toxicol. Appl. Pharmacol., 289: 251-261.

    48.    Yaseen Z, Rehman SU, Tabish M, Shalla AH and Ud-Din K. (2015). Modulation of bovine serum albumin fibrillation by ester bonded and conventional gemini surfactants. RSC Advances, 5: 58616-58624.

    49.    Husain MA, Rehman SU, Ishqi HM, Sarwar T and Tabish M. (2015). Spectroscopic and molecular docking evidence of aspirin and diflunisal binding to DNA: a comparative study. RSC Advances, 5: 64335-64345.

    2014

    50.    Yaseen Z, Husain MA, Rehman SU, Tabish M and Ud-Din K. (2014). Determination of the cationic amphiphilic drug-DNA binding mode and DNA-assisted fluorescence resonance energy transfer amplification. Spectrochim. Acta A Mol. Biomol. Spectrosc., 122: 553-564.

    51.    Rehman SU, Yaseen Z, Husain MA, Sarwar T, Ishqi HM and Tabish M. (2014). Interaction of 6 Mercaptopurine with calf thymus DNA-deciphering the binding mode and photoinduced DNA damage. PLOS ONE, 9: 4, e93913.

    52.    Yaseen Z, Rehman SU, Tabish M and Ud-Din K. (2014). Interaction between DNA and Cationic Diester Bonded Gemini Surfactants. J. Molec. Liquids, 197: 322-327.

    2013

    53.    Banday AR, Azim S, Hussain MA, Nehar S and Tabish M. (2013). Computational prediction and characterization of ubiquitously expressed new splice variant of Prkaca gene in mouse. Cell Biol. Int., 37(7): 687-693.

    54.    Husain MA, Yaseen Z, Rehman SU, Sarwar T and Tabish M. (2013). Naproxen intercalates with DNA and causes photocleavage through ROS generation. FEBS J., 280: 6569-6580.

    2012

    55.    Banday AR, Azim S and Tabish M. (2012). Differentially expressed three non-coding alternate exons at 5' UTR of regulatory type I beta subunit gene of mouse. Mol. Biol. Rep., 39(4): 3375-3383.

    56.    Azim S, Banday AR and Tabish M. (2012). Alternatively spliced three novel transcripts of gria1 in the cerebellum and cortex of mouse brain. Neurochem. Research, 37(1): 193-201.

    57.    Azim S, Banday AR and Tabish M. (2012). Identification of alternatively spliced multiple transcripts of 5-hydroxytryptamine receptor in mouse. Brain Res. Bull., 87(2-3): 250-258.

    58.    Banday AR, Azim S and Tabish M. (2012). Identification and expression analysis of three novel splice variants of protein kinase A catalytic ? subunit gene in the mouse using combinatorial in silico and molecular biology approaches. FEBS J., 279(4): 572-585.

    59.    Clegg RA, Bowen LC, Bicknell AV, Tabish M, Prescott MC, Rees HH and Fisher MJ. (2012). Characterization of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans. Arch. Biochem. Biophys., 519(1): 38-45.

    60.    Banday AR, Azim S, Rehman SU and Tabish M. (2012). Two Novel N-terminal coding exons of Prkar1b gene of mouse: Identified using a novel approach of in silico and molecular biology techniques. Gene, 500: 73-79.

    61.    Azim S, Banday AR, Sarwar T and Tabish M. (2012). Alternatively spliced variants of gamma-subunit of muscle type acetylcholine receptor in fetal and adult skeletal muscle of mouse. Cell. Mol. Neurobiol., 32: 957-963.

    2011 and before

    62.    Banday AR, Azim S and Tabish M. (2011). Alternative promoter usage and differential expression of multiple transcripts of mouse Prkar1a gene. Mol. Cell. Biochem., 357(1-2): 263-274.

    63.    Tabish M and Rodionov VI. (2010). Novel isoform of the Xenopus tropicalis PKA catalytic alpha subunit: An example of alternative splicing. Comp. Biochem. Physiol. Part D Genomics Proteomics, 5(2): 151-156.

    64.    Ashraf GM, Rizvi S, Naqvi S, Suhail N, Bilal N, Hasan S, Tabish M and Banu N. (2010). Purification, characterization, structural analysis and protein chemistry of a buffalo heart galectin-1. Amino Acids, 39: 1321-1339.

    65.    Kashyap L, Tabish M*, Ganesh S and Dubey D. (2007). Computational and molecular characterization of multiple isoforms of lfe-2 gene in nematode C. elegans. Bioinformation, 2(1): 17-21.

    66.    Kashyap L, Tabish M*, Ganesh S and Dubey D. (2007). Identification and comparative analysis of novel alternatively spliced transcripts of RhoGEF domain encoding gene in C. elegans and C. briggsae. Bioinformation, 2(1): 43-49.

    67.    Ola MS, Tabish M, Khan FH and Banu N. (2007). Purification and some properties of galectin-1 derived from water buffalo (Bubalus bubalis) brain. Cell Biol. Int., 31(6): 578-585.

    68.    Kashyap L and Tabish M. (2007). Alternatively spliced isoforms encoded by cadherin genes from C. elegans genome. Bioinformation, 2(1): 50-56.

    69.    Kashyap L and Tabish M. (2006). Comparative analysis of various gene finders specific to Caenorhabditis elegans genome. Bioinformation, 1(6): 203-207.

    70.    Tabish M. (2007). Expression of gamma-tubulin during the development of nematode C. elegans. Mol. Biol. Rep., 34(4): 233-40.

    71.    Bowen LC, Bicknell AV, Tabish M, Clegg RA, Rees HH and Fisher MJ. (2006). Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans. Cell. Signal., 18 (12): 2230-2237.

    72.    Tabish M, Clegg RA, Turner PC, Jonczy J, Rees HH and Fisher MJ. (2006). Molecular characterisation of cAMP-dependent protein kinase (PK-A) catalytic subunit isoforms in the male tick, Amblyomma hebraeum. Mol. Biochem. Parasitol., 150(2): 330-339.

    73.    Tabish M and Ticku MK. (2004). Alternate splice variants of mouse NR2B gene. Neurochem. Int., 44: 339-343.

    74.    Facanha AL, Appelgren H, Tabish M, Okorokov L and Ekwall K. (2002). The endoplasmic reticulum cation P-type ATPase Cta4p is required for control of cell shape and microtubule dynamics. J. Cell Biol., 157: 1029-1039.

    75.    Yoo EJ, Jin YH, Jang YK, Bjerling P, Tabish M, Hong SH, Ekwall K and Park SD. (2000). Fission yeast Hrp1, a chromodomain ATPase, is required for proper chromosome segregation and its over expression interferes with chromatin condensation. Nucleic Acids Res., 28: 2004-2011.

    76.    Tabish M, Clegg RA, Rees HH and Fisher MJ. (1999). Organization and alternative splicing of the Caenorhabditis elegans cyclic AMP-dependent protein kinase catalytic subunit gene (kin-1). Biochem. J., 339: 209-216.

    77.    Tabish M, Siddiqui ZK, Nishikawa K and Siddiqui SS. (1995). Exclusive expression of C. elegans osm-3 kinesin gene in chemosensory neurons open to the external environment. J. Mol. Biol., 247: 377-389. Cover of the issue was from this paper


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