Drug resistance mechanism, Drug designing, Biofilm, Photodynamic threrapy and infection control, Nanomedicine
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Dr. Asad U Khan graduated in Chemistry and did his post graduate in Biotechnology in 1994 and obtained a doctorate in Biochemistry from Aligarh Muslim University in association with International Centre for Genetic Engineering and Biotechnology, New Delhi.He joined as lecturer in 1997 and later proceeded for his post-doctoral research in RUTGERS University, New Jersey, USA during 2000-2003 for three years.
Currently he is Professor in Biotechnology Unit. Dr. Khan is recipient of many Fellowships and awards. He is recipient of BOYSCAST Fellowship of DST, Government of India to work as Visiting Scientist in one of the laboratories in University of Napoli, Italy during 2005. In year 2010. He has visited Hospital Biceter , Paris under DBT-CREST award programme of Department of Biotechnology. He has received grants from DST CSIR DBT ICMR and CCRUM.
Dr Khan is member of Editorial board of several International journals. He has edited Three books and author of over 240 Research articles in the peer reviewed journals with high impact factor with H-index of 41 (Scopus). (Research cited in Nature, Cell, EMBO J, Gen & Dev JBC etc). He is member of many national and international academic bodies.
On all these achievements Aligarh Muslim University conferred an Outstanding Research Award of the year to Prof Asad Ullah Khan on the day of Sir Syed day celebration in 2014. He is also recipient of most prestigious awards, National Bioscience Award of DBT, Government of India in 2012, Visitor's Award of 2019 and Om Prakash Bhasin Award , 2019. On administrative front Prof Khan served as coordinator (Head) of the Unit from 2012 to 2015 and 2018-2020
Moreover, he has also served as coordinator of DBT-BUILDER Progarmme and DST-PURSE programme of Ministry of Science and Technology, Government of India.
* Prof Asad U Khan appointed as Adjunct Professor in University of Catolica San Antonio de Murcia (UCAM) Spain for the period of two years.
* Prof Asad U Khan of Biotechnology, appointed as expert member of steering committee of UK Academy of Medical Sciences and Hamied Foundation UK-India AMR Programme.
Prof Asad U Khan of Biotechnology , Recognised as eminent researcher in the field of Antimicrobial Resistance by Government of India and research Council UK as per the prepared ?Scoping Report on Antimicrobial Resistance? in India which was released on November 2017 during Newton?s Award function in New Delhi.
On NDM-4 Discovery NEONA Film interviewed Prof Khan for a Documentary on Antibiotic Resistance; Link: https://www.youtube.com/watch?v=R61xH6Yl6h0 Important Awards and recognition: -Selected as Featured Article : https://bmcmicrobiol.biomedcentral.com/
Invited Blog for BMC Series: https://blogs.biomedcentral.com/bmcseriesblog/2017/04/28/human-destiny-post-antibiotic-era/
Khan, AU, Maryam, L and Zarrilli, R "Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health" BMC Microbiology (2017) 17:101 DOI: 10.1186/s12866-017-1012-8
Recipient of Visitor's Award of 2019
Recipient of Om Prakash Bhasin Award of 2019.
Recipient of Wockhardt Excellence Award of Jamia Hamdard 2018
-Elected Fellow of Royal Society of Chemistry, FRSC (London)
INSA-International Collaborating / Bilateral Exchange Programme Award 2017 of Indian National Science Academy Fellow of Biotech Research Society, India (2014)
Fellow of Indian Academy of Microbiological Sciences (2014) ?
First Recipient? of Outstanding Research Award of the Year 2014 conferred by AMU.
Recipient of National Bioscience Award for Career Development? (of Government of India, Department of Biotechnology for the year 2012.
Scival Solution of Elsevier an International publishing company recognized Asad U Khan as top third cited author and highest publication during 2008-2012 in Aligarh Muslim University
Thesis Advisor of 2012 Eli Lilly Outstanding Thesis Awardee Recipient of DBT-CREST Award of 2011 as visiting fellow in France Recipient of Most Active Teacher?s Award 2010 in AMU
Recipient of AGD Prize in 4rth Ditan International Conference on Infectious diseases held Beijing, China during July 15-18, 2010.
My Lab received Most Active Researcher Award of University in 2010
Recipient of AMI-ALEMBIC Award of 2009 in Medical Microbiology.
My Lab received Most Active Researcher Award of University in 2009 Recipient of Out Standing Merit Award of 2009 in AMU.
Recipient of Young Scientist Award of Association of Microbiologist of India in Medical Microbiology for the year 2006.
Indian National Science Academy Visiting Fellowship for the year 2006-07. BOYSCAST Fellowship of the year 2004-05 was awarded by Department of Science and Technology , Government of India, New Delhi.
Honorary Member of Advisory Board of Archives of Applied Sciences and Research. (2009-till date) Member of French public scientific organizations CNRS and INSERM to Review Grants.
Member of Netherlands Organization for Health Research and Development (ZonMw) to reviewer the grant proposals that have been submitted to the Priority Medicines Antimicrobial Resistance Programme.
Member of Bioinformatic and computational Biology Task Force in DBT, Ministry of Science and Technology, Government of India (2013-onward)
Member of Advisory committee of GBioFin, Gate to Biotechnology Industries, Organization and foundation, India ( 2014-onward.
Member of Organizing committee of 5th International conference on Proteomics and Bioinformatics held in Spain, during September 1-3, 2015. (https://proteomicsconference.com/organizing-committee.php )
Member of Organizing committee 6th International Conference and Expo on Proteomics held on March 29-30, 2016 in Atlanta, USA. https://proteomicsconference.com/america/organizing-committee.php Interviewed by TV channels and Electronic Media for NDM-4 Discovery:
LIVE MINT: https://www.youtube.com/watch?v=GWye03RIh0w French TV Times of India Hindustan Times My research of NDM-4 was taken for Documentary Film on Drug resistance by: Neona Films (https://www.youtube.com/watch?v=R61xH6Yl6h0)
Rare discoveries from our lab
i. First Discovery of NDM-1 in India from AU Khan?s Lab. ( Khan and Parvez, JMM , 2014).
ii. First reported NDM-4 producing Citrobacter freundii, (AK-82) co-associated with blaOXA-9, blaSHV-1 and blaCMY-149.
iii. First time identified NDM-4 producing Citrobacter braakii (AK-84), Klebsiella oxytoca (AK-100) and Enterobacter cloacae (AK-108) were identified in association with blaOXA-1 and blaCMY-145, blaOXA-1 and blaOXA-9 and, blaOXA-1, blaOXA-9 and blaCMY-149, respectively
iv. We have first time identified three NDM-4 producing Klebsiella pnemoniae with incompatibility group IncP in AK-97, AK-101 and AK-104 strains.
v. This study revealed outbreak of multiple variants of blaNDM (9; blaNDM-1, 16; blaNDM-4, 17; blaNDM-5, and 2; blaNDM-7) in clinically important bacteria (20 Escherichia coli, 18 Klebsiella pneumoniae, 02 Citrobacter freundii, 01 Citrobacter braakii, 01 Klebsiella oxytoca, 01 Enterobacter cloacae, 01 Enterobacter aerogenes. (Ahmad, N, et al. Front Microbiol. 2018 Mar 7;9:407)
vi. First reported New Delhi Metallo-β-lactamase-1 producing Cedecea lepagei. (Ahmad, N, et al. Int J Antimicrob Agents. 2017 Jan;49(1):118-119)
vii. This is the first report of blaNDM-4, blaNDM-5 and blaNDM-7 in E. arogenes species, isolated from the NICU of tertiary care hospital in India. (Ahmad, N, et al. Microb Drug Resist. 2018 Mar;24(2):161-165)
viii. We describe the first report novel ST3344 in two NDM-1 producing K. pneumoniae isolates from neonates admitted in NICU of one of the North Indian Hospitals. Moreover, these strains were also found to carry blaCTX-M-15, blaCMY-1 and blaSHV-1.
ix. We first time identified the co-producing strains of NDM and OXA-48 exhibited high MICs value of carbapenems.
x. This study explored varying replicon types (IncFIA, IncFIB, IncFIIAs, IncFIC, IncA/C, IncF, IncK, IncX, IncW and IncY), in these NDM-producing K. pneumoniae strain. (Ahmad, N, et al. Int J Antimicrob Agents. 2017 Jan;49(1):118-119)
xi. Co-existence of blaNDM-1 and blaVIM-1 producing Moellerella wisconsensis in NICU of North Indian Hospital: a first report (Ahmad, N, et al. 2019, J Infect Dev Ctries)
- Akhtar F, Khan AU, Misba L, Akhtar K, Ali A. “Antimicrobial and antibiofilm photodynamic therapy against vancomycin resistant Staphylococcus aureus (VRSA) induced infection in vitro and in vivo. Eur J Pharm Biopharm. 2021 Mar;160:65-76. doi: 10.1016/j.ejp
- Zuberi A, Ahmad N, Khan AU. “CRISPRi Induced Suppression of Fimbriae Gene (fimH) of a Uropathogenic Escherichia coli: An Approach to Inhibit Microbial Biofilms. Front Immunol. 2017 Nov 13;8:1552. doi: 10.3389/fimmu.2017.01552. eCollection 2017.PMID: 29181
- Farhat N, Ali A, Bonomo RA, Khan AU.”Efflux pumps as interventions to control infection caused by drug-resistance bacteria. Drug Discov Today. 2020 Dec;25(12):2307-2316. doi: 10.1016/j.drudis.2020.09.028. Epub 2020 Oct 1.PMID: 33011344 (IF: 7.8)
- Khan S, Khan SN, Akhtar F, Misba L, Meena R, Khan AU “Inhibition of multi-drug resistant Klebsiella pneumoniae: Nanoparticles induced photoinactivation in presence of efflux pump inhibitor.Eur J Pharm Biopharm. 2020 Dec;157:165-174. doi: 10.1016/j.ejpb.20
- Beg AZ, Khan AU “Motifs and interface amino acid-mediated regulation of amyloid biogenesis in microbes to humans: potential targets for intervention. Biophys Rev. 2020 Oct;12(5):1249-1256. doi: 10.1007/s12551-020-00759-5. Epub 2020 Sep 15.PMID: 32930961
- Khan SN, Khan S, Misba L, Sharief M, Hashmi A, Khan AU.” Synergistic fungicidal activity with low doses of eugenol and amphotericin B against Candida albicans. Biochem Biophys Res Commun. 2019 Oct 20;518(3):459-464. doi: 10.1016/j.bbrc.2019.08.053. Epub 2
- Parvez S, Misba L, Ahmad QT, Khan AU. “Emergence of Extremely Drug-Resistant and Uropathogenic New Delhi Metallo-?-Lactamse-6 (blaNDM-6)-producing Citrobacter werkmanii. Int J Antimicrob Agents. 2019 May;53(5):703-704. doi: 10.1016/j.ijantimicag.2019.02.0
- Ali A, Gupta D, Khan AU. “Role of non-active site residues in maintaining New Delhi metallo-?-lactamase-1(NDM-1) function: an approach of site directed mutagenesis and docking. FEMS Microbiol Lett. 2019 Jan 9. doi: 10.1093/femsle/fnz003. Online ahead of p
- Ahmad N, Ali SM, Khan AU. “Molecular characterization of novel sequence type of carbapenem-resistant New Delhi metallo-?-lactamase-1-producing Klebsiella pneumoniae in the neonatal intensive care unit of an Indian hospital. Int J Antimicrob Agents. 2019 A
- Khan AU, Ali A, Danishuddin, Srivastava G, Sharma A “Potential inhibitors designed against NDM-1 type metallo-?-lactamases: an attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria. Sci Rep. 2017 Aug 23;7(1):9207. doi: 10.1038
- Zuberi A, Misba L, Khan AU.”CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. coli: An Approach to Inhibit Biofilm. Front Cell Infect Microbiol. 2017 May 26;7:214. doi: 10.3389/fcimb.2017.00214. eCollection 2017.PMID: 28603699 (IF: 4)
- Khan AU, Rehman MT Role of Non-Active-Site Residue Trp-93 in the Function and Stability of New Delhi Metallo-?-Lactamase 1.. Antimicrob Agents Chemother. 2015 Nov 2;60(1):35660. doi: 10.1128/AAC.01194-15. Print 2016 Jan.PMID: 26525789 (IF: 4.7)
- e X, Khan AU, Cheng H, Pappas DL Jr, Hampsey M, Moore CL. “Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1. Genes Dev. 2003 Apr 15;17(8):1030-42. doi: 10.1101/gad.1075203.PMID: 12704082 (
- Khan AU, Hampsey M. “Connecting the DOTs: covalent histone modifications and the formation of silent chromatin.Trends Genet. 2002 Aug;18(8):387-9. doi: 10.1016/s0168-9525(02)02746-4.PMID: 12142001 (IF: 11)