DEPARTMENT.FACULTY
- DEPARTMENT_STAFF.QUALIFICATION
Ph.D, FRSC
- DEPARTMENT_STAFF.DESIGNATION
Professor
- DEPARTMENT_STAFF.THRUST_AREA
1.Medicinal Inorganic Chemistry, Synthesis & characterization of Metal-based antitumour therapeutic agents 2. Interaction studies of Metal-based drug entities with ctDNA &tRNA using biophysical methods 3. metallodrug enties targeted to G-quadruplexes and CSC's
- DEPARTMENT_STAFF.ADDRESS
B-64,Gulistan Housing Complex,Anoopshahar Road ,Near FM Tower,Maheshpur, Aligarh,UP 202002,India.
- DEPARTMENT_STAFF.MOBILE
9897157511
- DEPARTMENT_STAFF.EMAIL
farukh.arjmand18@gmail.com
- DEPARTMENT_STAFF.TIME_TABLE
Dr. Farukh
Arjmand is currently working as a Professor of Chemistry at Aligarh Muslim
University, Aligarh, India. Dr. Arjmand has 30 years
of research and teaching experience in the area of Inorganic Chemistry, in
particular, “Medicinal Inorganic Chemistry”. She is working on
the Molecular design and synthesis of new metallodrug antitumor
therapeutic candidates derived from bioactive ligand scaffolds with 3d
transition and organotin(IV) metal ions. Her research group has isolated many
promising tailored metallodrugs, and antitumor candidates, their structure
elucidation was done by spectroscopic and single X-ray crystal diffraction
methods, and their potential to act as anticancer chemotherapeutic agents were
validated by DNA/RNA binding affinity, cleavage activity and cytotoxicity
profile against a panel of human cancer cell lines and molecular docking
experiments. She has published 188 research
papers in journals of international repute ( with highest impact 24.83) and, contributed many articles
to national/international conferences and symposiums, delivered many invited
lectures and has (2+1) three patents on metallic antitumor
drug entities. Dr. Arjmand has 5549 citations (Scopus) to
her credit with h-index 42 and i10-index 115.
Prof. Arjmand has successfully guided 18 Ph.D’s., 4 M.Phil.’s
and 17 Master’s project students and has run six major
research projects as Principal investigator (PI) on the design of metal-based
drug candidates awarded by UGC, CSIR,
and DBT, Govt. of India, and has visited many countries
(China, USA, Egypt) for academic pursuits. She has joint research
collaborations with national and international research institutes, IIT
Kharagpur, IICT, Hyderabad and ACTREC, Mumbai, India, USTC, China and Institut
de Physique de Rennes, France, and The Ohio State University, USA. Prof Arjmand
has received many prestigious awards viz., Young Scientist, ICC,2005,
the Distinguished Women Scientist Award 2016 , ISCB , 2017,
and the CRSI Bronze Medal 2019, Chemical Research Society of
India, CRSI) and Outstanding Researchers Award 2022
in faculty of science and Life science, A.M.U . Prof Arjmand was awarded
prestigious
FRSC in 2023
( Membership number: 679931) by Royal
Society of Chemistry, UK
for her
contribution to chemical science and chosen as CRSI council member in 2020 for three years
. Prof Arjmand is presently
serving as Editor, Journal of Molecular Structure, Elsevier. She completed the
Academic leadership (LeAP) program, MHRD, Govt. of India at
AMU, India, and OSU, USA in 2019.
- Publication
Biochemical Pathways of Copper Complexes: progress over the past 5 years , SiffeenZehra, Sartaj Tabassum, Farukh Arjmand, Drug Discovery Today, 2021, doi.org/10.1016/j.drudis.2021.01.015.
Water soluble ionic Co(II), Cu(II) and Zn(II) diimine–glycinate complexes targeted to tRNA: structural description, in vitro comparative binding, cleavage and cytotoxic studies towards chemoresistant prostate cancer cells, Siffeen Zehra, Santiago Gómez-Ruiz, Hifzur R. Siddique, Sartaj Tabassum and Farukh Arjmand, Dalton Trans., 2020,49, 16830-16848
- RNA-targeted Cu(II)-based Potential Antitumor Drug Entity: Comprehensive Structural, Biological {DNA/RNA binding, Cleavage, Cytotoxicity} and Computational Studies. Sabiha Parveeen, Kaneez Fatima, Siffeen Zehra and Farukh Arjmand, J. Biomol. Struct. Dyn., (2020).
- RNA-targeted Cu(II)-based Potential Antitumor Drug Entity: Comprehensive Structural, Biological {DNA/RNA binding, Cleavage, Cytotoxicity} and Computational Studies. Sabiha Parveeen, Kaneez Fatima, Siffeen Zehra and Farukh Arjmand, J. Biomol. Struct. Dyn., (2020).
- Copper(II) l/d-valine-(1,10-phen) complexes target human telomeric G-quadruplex motifs and promote site-specific DNA cleavage and cellular cytotoxicity, Farukh Arjmand, Surbhi Sharma, Sabiha Parveen, Loic Toupet, Zhen Yu , J. A. Cowan, Dalton Trans., 2020, Advance Article.
- Enantiomeric copper based anticancer agents promoting sequence-selective cleavage of G-quadruplex telomeric DNA and non-random cleavage of plasmid DNA, Sabiha Parveen, J. A. Cowan, Zhen Yu, Farukh Arjmand, Metallomics, 2020,12, 988-999.
- New Tailored RNA-Targeted Organometallic Drug Candidates against Huh7 (Liver) and Du145 (Prostate) Cancer Cell Lines, Huzaifa Yasir Khan, Santosh K. Maurya, Hifzur R. Siddique, Shariq Yousuf, Farukh Arjmand, ACS Omega, 2020, 5, 25, 15218–15228.
- Molecular docking, DFT and antimicrobial studies of Cu (II) complex as topoisomerase I inhibitor, Shazia Parveen, Farukh Arjmand, Qianfan Zhang, Musheer Ahmad, Arif Khan, Loic Toupet, J. Biomol. Struct. Dyn., 2020, 1-14.
- Structure elucidation {spectroscopic, single crystal X-ray diffraction and computational DFT studies} of new tailored benzene sulfonamide derived Schiff base copper(II) intercalating complexes: Comprehensive biological profile {DNA binding, pBR322 DNA cleavage, Topo I inhibition and cytotoxic activity}, Zeenat Afsan, Thierry Roisnel, Sartaj Tabassum, Farukh Arjmand, Bioorganic Chemistry, 94 (2020) 103427.
- Evaluation of cytotoxic potential of structurally well–characterized RNA targeted Ionic Non–steroidal anti–inflammatory (NSAID) Cu(II) & Zn(II) DACH–mefenamato drug conjugates against human cancer cell lines. Huzaifa Yasir Khan, Sartaj Tabassum and Farukh Arjmand, RSC Advances, 10 (2020) 166–178.
- Recent advances in metallodrug-like molecules targeting non-coding RNAs in cancer chemotherapy, Farukh Arjmand, Zeenat Afsan, Surbhi Sharma, Sabiha Parveen, Imtiyaz Yousuf, Sara Sartaj, Hifzur R. Siddique, Sartaj Tabassum, Coord. Chem. Rev.,387, ( 2019), 47-59.
- Enantiomeric Amino Acid Schiff Base Copper(II) Complexes as a New Class of RNA-Targeted Metallo-Intercalators: Single Xâ??ray Crystal Structural Details, Comparative in Vitro DNA/RNA Binding Profile, Cleavage, and Cytotoxicity, Siffeen Zehra,Thierry Roisnel, and Farukh Arjmand, ACS Omega, 4 (2019) 7691?7705.
- Spectroscopic and single X-ray crystal diffraction studies of enantiomeric copper(II) Schiff base 1D-coordination polymers with 4-(2-aminoethyl)benzenesulfonamide appendage: comprehensive biological evaluation {DNA binding, cleavage, SOD mimetic activity, Topo I inhibition and cytotoxicity}, Zeenat Afsan, Thierry Roisnel, Sartaj Tabassum, Farukh Arjmand, Appl. Organomet. Chem., (2019).
- Single X-ray crystal structure, DFT studies and topoisomerase I inhibition activity of a tailored ionic Ag(I) nalidixic acid–piperazinium drug entity specific for pancreatic cancer cells. Imtiyaz Yousuf, Mohammad Usman, Musheer Ahmad, Sartaj Tabassum and Farukh Arjmand, New J. Chem., 42 (2018) 506–519.
- Vibrational dynamics (IR, Raman, NRVS) and a DFT study of a new antitumor tetranuclearstannoxane cluster, Sn(IV)-oxo-{di-o-vanillin} dimethyl dichloride, Farukh Arjmand, Surbhi Sharma, Mohammad Usman, B. M. Leu, M.Y. Hu, Loic Toupet, D. gosztola and Sartaj Tabassum, Phys. Chem. Chem. Phys., 2016, 18, 17805-17809
- Synthesis and characterization of Co(II) and Fe(II) peptide conjugates as hydrolytic cleaving agents and their preferential enantiomeric disposition for CT–DNA: Structural investigation of L–enantiomers by DFT and molecular docking studies. Sabiha Parveen, Mohammad Usman, Sartaj Tabassum and Farukh Arjmand, RSC Adv., 2015, 5, 72121-7213
- A Comprehensive biological insight of trinuclear Copper(II)tin(IV) chemotherapeutic anticancer drug entity: in vitro cytotoxicity and in vivo systemic toxicity studies,Yusra Zaidi, Farukh Arjmand, Nida Zaidi, Jawed Usmani, Haseeb Zubair, Kafil Akhtar, Mobarak Hossain, G. G. Hammad Shadab, Metallomics (2014) 6, 1469-1479, (2014).
- Design and synthesis of S– and R– enantiomers of [4–(2–hydroxy–1–phenylethylamine)pent–2-ol]dimethyltin(IV) and 2,2–dimethyl–4–phenyl–1,3,2–oxazastannolidine: In vitro and in vivo antitumor activity of their S–enantiomer against human tumor cell lines, Farukh Arjmand, Fatima Sayeed, Shazia Parveen, Sartaj Tabassum, Aarti S. Juvekar, Surekha M. Zingde, Dalton Trans. 42, 3390–3401 (2013).
- DNA binding studies of novel copper (II) complexes containing L–tryptophan as chiral auxiliary : In vitro antitumor activity of Cu–Sn2 complex in human neuroblastoma cells, M. Chauhan, K. Banerjee and Farukh Arjmand, Inorg. Chem. 46, 3072 (2007).